Drug desensitization is a process in which a drug to which the patient is allergic is administered to the patient in small, incremental doses to induce a state of temporary tolerance to the drug. This should only be attempted if the offending drug is deemed essential and no alternatives are available. This treatment has been well established for IgE-mediated drug allergy, specifically to penicillins.

Drug desensitization for non–IgE-mediated drug allergy has also been described for various drugs. Although treatment has been shown to be effective, the underlying mechanisms for its success remain unknown.

In some situations, rapid desensitization in a few hours may be required.  In addition, desensitization over a period of days to weeks may be acceptable if the need is for prophylaxis or more chronic treatment. Desensitization via the oral route may be safer than by the IV (parenteral) route, but the process is dependent on adequate absorption and may be complicated by vomiting. A beginning dose can be selected as a fraction, possibly 1/100 or 1/1000 of the subject ’s known tolerance of the agent or by arbitrarily starting with 1:1000 to 1:10,000 dilution of the therapeutic concentration. Subsequent doses are then increased by doubling. After the therapeutic concentration (dose) is reached, the patient should continue to receive the agent.

Induction of tolerance to the offending drug is temporary and patients are still regarded as allergic to that particular drug. Should the patient require the medication 3-7 days after stopping desensitization, then the process should be reinstituted.

Desensitization protocols have been described for many drugs including penicillins, cephalosporins, Cotrimoxazole, Allopurinol, and chemotherapeutic agents.

Drug Allergy & Desensitization Treatment in Los Angeles | Drug Desensitization Therapy & Drug Allergy Clinic Los Angeles

Allergy, Asthma & Sinus Clinic offers cutting-edge Drug Desensitization Treatment in Los Angeles, providing relief for individuals fighting with allergies and asthma. Led by the renowned Dr. Asif Rafi, our clinic specializes in personalized Drug Desensitization Therapy, a groundbreaking approach to manage allergies effectively. Are you searching for Drug Desensitization Treatment Near Me in Los Angeles? Look no further. Our clinic is conveniently located to serve the local community, offering a state-of-the-art facility equipped with the latest advancements in allergy and asthma care. Dr. Asif Rafi, a distinguished expert in the field, leads our Drug Desensitization Clinic in Los Angeles. With a commitment to patient well-being, Dr. Rafi employs a tailored approach to drug desensitization, customizing treatments to address individual needs. 

 Drug Desensitization therapy is designed to gradually expose patients to increasing amounts of the allergen, building tolerance over time and reducing sensitivity. Our clinic prioritizes patient comfort, safety, and results. Dr. Asif Rafi’s extensive experience in allergy and asthma management ensures that you receive the highest standard of care. Whether you’re dealing with environmental allergies, food sensitivities, or medication reactions, our clinic is dedicated to finding a solution that works for you.

Discover a path to a life with fewer allergy and asthma symptoms. Contact Allergy, Asthma & Sinus Clinic today to schedule a consultation with Dr. Asif Rafi and explore the benefits of Drug Desensitization Therapy in Los Angeles. Take the first step towards a healthier, more comfortable life.